By David F. Keren
The second one version of this recognized explication of the recommendations and interpretations of electrophoresis and immunofixation has been completely up-to-date. Incorporating the alterations in expertise because the first variation was once released, the writer has made broad revisions, fullyyt changing the part on immunoelectrophoresis with a dialogue of the present means of immunofixation. the vast majority of the unique illustrations were revised, and a brand new part at the interpretation of oligoclonal bans in cerebrospinal fluid has been incorporated
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Extra resources for High-Resolution Electrophoresis and Immunofixation. Techniques and Interpretation
Although its name implies that its functions are limited to inhibiting the activity of trypsin, alpha-1 antitrypsin interferes with the enzymatic activity of a variety of enzymes, including trypsin, chymotrypsin, pancreatic elastase, skin collagenase, renin, urokinase, Hageman-factor cofactor, and leukocyte-neutral proteases [32,33]. It is by far the most significant protease inhibitor in serum, accounting for more than 90% of the trypsin-inhibiting capacity of human serum . In the lung, it binds to and inhibits the proteolytic activity of neutrophil elastase.
DENSITOMETRIC SCANNING OF HIGH-RESOLUTION ELECTROPHORESIS There is unanimity that HRE gels should be evaluated by direct visual inspection after staining. Direct inspection of the gels provides a qualitative assessment that is used in pattern interpretation (see Chapter 3). Furthermore, currently available densitometers are not sensitive enough to detect subtle changes in migration of protein bands such as in alpha-1 antitrypsin variants, small monoclonal gammopathies (especially those in the beta region that may be obscured by the other proteins in that region), and oligoclonal patterns .
Densitometnc scan from analbuminemic patient. Only minor background distortions are seen in the albumin area (A). [Figures contributed by Carl R. M. )]. variants of albumin will migrate anodally to the normal position and others will migrate cathodally. The albumin variant depicted in Figure 3-5 migrates cathodally to the normal albumin. Clinically, bisalbuminemia (alloalbuminemia) has no pathologic consequences . The incidence varies depending on the population, with a range of 1:1,000 to 1:10,000 in Caucasians and Japanese, but with a frequency as high as 1% in some American Indian tribes [24,25].