Organic Chemistry

Download Bioorganic and Medicinal Chemistry of Fluorine by Jean-Pierre Bégué PDF

By Jean-Pierre Bégué

  • offers an intensive evaluate of the function of fluorine in pharmaceutical technology and improvement
  • contains chapters on fluorinated analogues of ordinary items, fluorinated amino acids and peptides, and derivatives of sugars
  • Classifies advertised and in-development fluorinated prescription drugs in keeping with their healing sessions
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    J. A. Jamois, J. Fluorine Chem. 1991, 53, 79. 16. K. Mikami, Y. Itoh, and M. Yamanaka, in Fluorine-Containing Synthons, V. , ACE Symposium Series 911, ACS, Washington DC, 2005, p. 358. 17. A. W. Taft, F. Z. Q. S. D. M. L. M. Vlasov, R. C. Maria, J. Am. Chem. Soc. 1994, 116, 3047. J. B. Wiberg, J. Org. Chem. 1998, 63, 3937. 18. H. L. V. J. J. Taylor, J. Chem. , Perkin Trans. 1990, 521. 19. K. G. E. Osterberg, Chem. Rev. 1994, 94, 373. 20. J. A. Volkmann, J. Am. Chem. Soc. 2000, 122, 466. 21. W. Caminati, S.

    119 The isolation of the silylacetal ketene is required when the reaction is catalyzed by a chiral Lewis acid. However, due to its instability, isolation yields of the compounds are very low. 120 This latter compound is more stable than the corresponding silyl ketene acetal. , aldehydes, imines, activated halides) in the presence of fluoride ions. 28 Preparation and reaction of trimethylsilyldifluoroacetate. Remarks: Preparation of difluorophosphonates. The preparation of difluorophosphonates is detailed in Chapter 7 (enzyme inhibitors).

    205. S. K. Yudin, Chem. Rev. 1997, 97, 757. P. M. Shreeve, Tetrahedron 2000, 56, 7613. 43. J. Burton and L. Liu, Fluorinated organometallic compounds in organic chemistry, in Current Topics in Chemistry No. D. , Springer, Berlins, 1997, p. 45. G. J. O’Reilly, J. Org. Chem. 1987, 52, 2481. 44. G. J. Stewart, and P. Tarrant, J. Org. Chem. 1967, 33, 280. 45. T. M. D. Wilkes, Tetrahedron 1995, 51, 9201. 46. A. Takaoka, H. Iwakiri, and N. Ishikawa, Bull. Chem. Soc. Jpn. 1979, 52, 3377. 47. D. Chambers, Fluorine in Organic Chemistry, Wiley, Hoboken, NJ, 1973.

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