By F. Vögtle, E. Weber, J. Franke, A. Gärtner, H. Nishide, F.P. Schmidtchen, E. Tsuchida, U. Weser
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Extra resources for Biomimetic and Bioorganic Chemistry II
The activity was attributed to an interference o f iron-EDTA with the assay mixture. More recently, the SOD-activity o f i r o n - E D T A was confirmed, using pulse radiolysis 274) Fe(III)-EDTA chelates react with the superoxide radical at physiological pH-values, but the reaction constant is lower at alkaline pH. The reaction proceeds according to the following equations: Fe 3 + - - E D T A + Oi- ~ Fe 2 + (26) E D T A + O2 (27) Fe 2 + - - E D T A + Oi- --* Fe 3 + - - E D T A -- 022Fe s + - - E D T A - - 0 2- + 2 H + ---, Fe 3 + - - E D T A + H202 (28) The formation of a peroxo complex (Eq.
The method is practicable in crude homogenates, like extracts of the red blood cell. The work with radioactive tracers, however, has some disadvantages. If the highly sensitive detection limit is not required, the classical electroimmunoassay can be used. Electroimmunoassay In an electric field SOD migrates on agarose gels because it has a net charge at physiological pH-values. If antibodies are added, an antigen-antibody complex is formed which precipitates under the appropriate conditions 166).
There is a polarization between one group which debates the biological importance of the dismutation of superoxide and another one which is convinced that this reaction is required in aerobic metabolism, preventing the organism from an attack of reactive oxygen species. The current knowledge does not allow a definite 46 Molecular and Functional Aspects of SuperoxideDismutases solution to this problem. The present aim will be a brief discussion of the arguments of either group. 02 supplied at concentrations higher than those in normal air causes damage to plants, animals and aerobic bacteria 280).