Organic Chemistry

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By Alois Fuerstner

Content material: Olefin metathesis by way of well-defined complexes of molybdenum and tungsten / R.R.Schrock -- Ruthenium-catalyzed metathesis reactions in natural synthesis / A. Furstner -- Ring-closing metathesis within the synthesis of epothilones and polyether ordinary items / K.C. Nicolaou, N.P. King, Y. He -- Catalytic ring-closing metathesis and the advance of enantioselective methods / A.H. Hoveyda -- Enyne metathesis / M. Mori -- Cross-metathesis / Susan E. Gibson, S.P. willing -- contemporary advances in ADMET chemistry / D. Tindall, J.H. Pawlow and K.B. Wagener -- Bioactive polymers / L.L. Kiessling, L.E. powerful

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This review also covers the application of these tools to advanced organic synthesis, with the focus being on the ring closing meta- Fig. 1. Ruthenium-Catalyzed Metathesis Reactions in Organic Synthesis 39 thesis (RCM) of dienes to cycloalkenes of all ring sizes. Finally, some recent investigations on metathesis reactions in supercritical carbon dioxide (scCO2) will be summarized [7], since this unconventional reaction medium may eventually upgrade the industrial application profile of such transformations for the production of fine chemicals.

O O Et O 6% MoF6 O Et (39) 91% CO2Me CO2Me 28 Richard R. Schrock RO RO 1. 3 % Mo (40) 2. 6]bicycle was also prepared readily. Hoveyda and coworkers have used a Mo-catalyzed RCM step in the enantioselective total synthesis of antifungal agent SCH-38516 (Eq. 41) [220, 221]. In a recent full paper [46] it was discovered that freshly prepared or recrystallized Mo catalyst allowed ring-closing metathesis to occur smoothly at 22˚C to afford the cyclic product shown in Eq. 41 in 90% yield after only 4 h.

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