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Download Age-related Macular Degeneration by L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. PDF

By L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. Vingerling, C. C. W. Klaver (auth.), Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide, Alan C. Bird (eds.)

Age-related macular degeneration is the commonest reason for the lack of crucial imaginative and prescient past the age of fifty in commercial international locations. Triplication of the variety of affected sufferers is anticipated over the subsequent 25 years. specially during the last years the normal of data relating to etiology, probability components, diagnostics and remedy of this retina disorder has considerably grown – it will be coated during this up to date multi-authored paintings. except epidemiologically and genetically pointed out chance elements either some of the pathophysiological elements together with the function of the supplement process and medical manifestations together with OCT and angiographic features are essentially represented. in addition, different healing techniques are provided and mentioned, together with confirmed strategies comparable to intravitreal anti-VEGF remedy and seeing-aid structures, as well as the newest and upcoming equipment within the quarter of pharmacology. the amount is well-illustrated and tables and summaries entire the presentation.

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7% in the population-based Rotterdam Study [127]. These findings further support the notion of racial/ethnic differences in allele frequencies and genetic susceptibility to AMD. 4 Complement Factor I (CFI) CFI is regulated by CFH and functions as a cofactor for the cleavage and inactivation of C3b. Recently, several variants near CFI have been associated with risk of AMD in Caucasian as well as Asian populations [133– 137]. 69) for homozygous carriers of the minor “C” allele. 62). 45). Ennis et al.

41) [244, 245]. Conversely, two other groups reported no correlation [243, 246]. The ABCA4 (ABCR) gene produces an ATP-binding cassette superfamily transmembrane protein expressed exclusively in retinal photoreceptors which is involved in the clearance of all-trans-retinal aldehyde–a by-product of the retinoid cycle of vision–from photoreceptor cells. Alleles at the ABCA4 gene were initially associated with an increased risk of AMD. 4) [247–249]; however, subsequent research has contradicted this.

69). 41). 17). 14) [293]. Contrarily, the BMES found no evidence of an association between pulse pressure, systolic or diastolic blood pressure, or presence of hypertension at baseline and incident AMD [289]. 5 Cataract Surgery There have been reports of an association between cataract surgery and AMD [294–304]. Cross-sectional data from the BDES showed an association between cataract surgery and early AMD [295]. In the NHANES (National Health and Nutrition Examination Survey), a cross-sectional association was reported between aphakia and AMD [294].

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