Organic Chemistry

Download Advanced Organic Reactions by Rizzo C.J. PDF

By Rizzo C.J.

Show description

Read Online or Download Advanced Organic Reactions PDF

Similar organic chemistry books

Materials-Chirality

Subject matters in Stereochemistry, Materials-Chirality offers complete details at the stereochemistry of fabrics. insurance comprises the chirality of fabrics and the $64000 position stereochemistry performs within the actual homes of polymers, liquid crystals, and different fabrics.

Houben-Weyl Methods in Organic Chemistry: Oraganophosphorus Compounds

Methoden der Organischen Chemie (Methods of natural Chemistry, referred to as Houben-Weyl) is a regular reference paintings for chemists engaged in natural synthesis. In volumes on compound periods, together with all Supplemental volumes, preparative tools are handled comprehensively and significantly. Tables of examples evaluate crucial tools and convey their scope.

Additional info for Advanced Organic Reactions

Example text

Na (MeOCH2CH2O)2AlH2 REDAL OH 48 REDUCTIONS 49 Chem. Rev. 1986, 86, 763 Org. Rxn. 1951, 6, 469. Lithium Aluminium Hydride LiAlH4 (LAH) - very powerful reducing agent - used as a suspension in ether or THF - Reduces carbonyl, carboxylic acids and esters to alcohols - Reduces nitrile, amides and aryl nitro groups to amines - opens epoxides - reduces C-X bonds to C-H - reduces acetylenic alcohols trans-allylic alcohols LAH OH R OH R H2N LAH, THF N H NH 2 H2N (62%) NH 2 N H NH 2 Lindlar/ H2 H2N O N H HO CO 2Me OH LAH, THF, ↑↓ TL 1988, 29 , 2793.

1962, 12, 356; Chem. Rev. 1962, 62, 347. R R S R Raney Nickel R H R H (CH 2)n O R S 31 REDUCTIONS O O O O O HO 32 O HO Raney Nickel JOC 1987, 52, 3346 EtOH (74%) H S H S Homogeneous Catalytic Hydrogenation - catalyst is soluble in the reaction medium - catalyst not "poisoned" by sulfur - very sensitive to steric effects - terminal olefins faster than internal; cis olefins faster than trans R R > > R R R R > R R R > R R >> R R R - (Ph3P)3RhCl (Wilkinson's Catalyst); [R3P Ir(COD)py]+ PF6- (Crabtree's Catalyst) (Ph3P)3RhCl, H2 OH OH JOC 1992, 57, 2767 C 6H6 (92%) Directed Hydrogenation Review: Angew.

Li (tBuO)3AlH 4. (iBu)2AlH DIBAL-H 5. Na (MeOCH2CH2O)2AlH2 REDAL OH 48 REDUCTIONS 49 Chem. Rev. 1986, 86, 763 Org. Rxn. 1951, 6, 469. Lithium Aluminium Hydride LiAlH4 (LAH) - very powerful reducing agent - used as a suspension in ether or THF - Reduces carbonyl, carboxylic acids and esters to alcohols - Reduces nitrile, amides and aryl nitro groups to amines - opens epoxides - reduces C-X bonds to C-H - reduces acetylenic alcohols trans-allylic alcohols LAH OH R OH R H2N LAH, THF N H NH 2 H2N (62%) NH 2 N H NH 2 Lindlar/ H2 H2N O N H HO CO 2Me OH LAH, THF, ↑↓ TL 1988, 29 , 2793.

Download PDF sample

Rated 4.48 of 5 – based on 16 votes